The study found that LIGHT plays an important role in critical viral pneumonia

Academic journal Science Bulletin published the research paper "LIGHT of Pulmonary NKT cells annihilates tissue protective alveolar macrophages in the augmentation severe pneumonia" (https://doi.org/10.1016/j.scib.2021.01.026).
study found that LIGHT, a member of the tumor necrosis factor super family (TNFSF), was an important inflammatory factor for highly pathogenic influenza lung injury.
flu virus invades the lower respiratory tract, damaging the bronchial mucous membrane epithelial and vesicle microvascular.
the body to initiate an inflammatory immune response, remove the virus, repair damaged tissue.
, however, critical viral pneumonia, including influenza and neo-crown pneumonia, often causes acute respiratory distress syndrome (ARDS) and sepsis due to excessive release of inflammatory factors, with a high death rate.
tumor necrosis factor (TNF) is a common viral pneumonia causative factor, yet the role of LIGHT, another member of the family, in pneumonia caused by highly pathogenic influenza viruses has rarely been studied.
Assistant Researcher Shi Lina and Yang Yan, Ph.D. students at the University of Chinese Academy of Sciences, found that influenza virus infection can cause natural killer cells (NK) and natural killer T-cells (NKT) to invade lung tissue, and activated NKT cells are the main source of secretion of LIGHT cells, and are the main inflammatory factors of lung damage caused by highly pathogenic influenza virus infection.
another natural type of immune cell in the alba bubble, the albbly macrophage (AMs), is not only an important antiviral immune cell in the al bubble, but also essential for remodeling and repairing the albbly tissue after damage.
LIGHT has two membrane subjects in AMs, HVEM and LT beta R, and light inspired by the highly pathogenic influenza virus causes the death of AMs cells through LT beta R, which does not affect the anti-flu virus ability of mice, but does not repair the damage, aggravates the occurrence and development of ARDS, and increases the mortality rate in mice.
is unique, with Science magazine recently reporting that light increases are common in critically ill new crown patients receiving intensive care units (ICUs).
suggests that LIGHT may be an inflammatory factor in critically ill viral pneumonia, associated with prognosis and mortality.
study of NKT cells and their LIGHT will help to find new ways of this type of disease.
this research has been funded by the Chinese Academy of Sciences, the Ministry of Science and Technology and the National Natural Science Foundation of China, and is another research achievement of great clinical value of the Collaborative Innovation Center for Infectious Disease Immunology and Treatment at the Shanghai Science and Technology Center.
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