The use of vancomycin powder at the surgical site to reduce infection rate

Ref:Mallela AN,et al..
 2017 Dec 18doi: 10.1093/neuros/nyx559(Epub ahead of print)surgical-site infection (surgical-site infections, SSIs) is a common in-hospital acquired infection associated with mortality in neurosurgery patientsPrevious studies have shown that local use of vancomycin powder reduces the risk of SSIs for craniofacial and spinal surgeryArka NMallela of Neurosurgery at the University of Pennsylvania Hospital conducted a large single-center forward-looking cohort study to analyze the effects of local use of vancomycin powder on SSIs during craniofacial surgery, published online in December 2017355 patients were included in the study between June 2013 and December 2015Inclusion criteria: (1) age 18 years old; (2) open craniofacial surgery; (3) surgery to clean the incisionAmong them, the experimental group of 205 cases, when off the skull under the cap tendon membrane sprayed 1g vancomycin powder (Figure 1); The main observation indicators were the incidence of bacterial culture-positive SSIs within 120 days of surgery, and the secondary observation indicators were the hospitalization costs caused by SSIsFigure 1 Spray vancomycin powder under the cap tendon membrane when closing the skull The average follow-up time for patients was 658 to 29 days after surgery The results showed that the incidence of SSIs in the experimental group was significantly lower than that of the control group, and was 0.49% vs 6% (P-0.002) Additional medical expenses incurred by SSIs saved $1367,446 in local use of vancomycin powder per 1,000 open-craniofacial patients In addition, there are no side effects in local application of vancomycin , the results suggest that neurosurgeons can use vancomycin to prevent SSIs in the area of craniofacial surgery; (Feng Menglong, of Xiangnan College Hospital, compiled , editor-in-chief of "Outside The Sun Information" and Professor Chen Rongcheng , affiliated with Fudan University), related links