Ther Adv Ophthalmol: Effect of systemic drug selection on prognosis in patients with diabetic central retinal vein obstruction

Background; Retinal vein occlusion (RVO) is the second most common vision-threatening retinal vascular disease after diabetic retinopathy

Diabetes is a known risk factor

Several systemic hypoglycemic agents, including metformin, sodium-glucose cotransporter-2 inhibitors, and glucagon-like peptide-1, have been associated

ObjectiveTo evaluate the effect

Methods: From 2009 to 2017, a retrospective longitudinal cohort study was conducted at a tertiary academic referral center to investigate the eyes

Results: We identified 138 eyes of 138 participants who had diabetes

Table 1 Clinical features

Figure 1 Distribution

Table 2 CRVO ocular imaging features

CONCLUSIONS: Although aspirin 325 mg, metformin, sitagliptin, and glipizide were associated with better VA, lower CST, lower prevalence of macular edema at final presentation, and lower final CST, respectively, these systemic drugs or glycemic control were not associated

Simmons K, Singh P, Borkar DS,et al.