Recently, Tianjin University Medical Department Zhang Xiaodong team successfully designed a new type of artificial enzyme - "cluster enzyme."
"cluster enzyme" has super catalytic activity and selectivity, the potential for the treatment of alzheimer's disease, brain injury and other neuro-inflammation is huge, the results have been published online in the international authoritative journal Nature Communications.
is an important catalyst in the organism, and it is a catalytic organic matter produced by living cells.
enzyme catalysis can increase the speed of chemical reactions by more than 100 times at room temperature and pressure, and has great application value in the field of medicine for neurology, tumor, biological sensing, etc., and is also widely used in agriculture, food, chemical and other fields.
, most natural enzymes are difficult to prepare, poor stability, harsh catalytic conditions, difficult to apply on a large scale.
how to design artificial enzymes with high catalytic activity and selectability has become a common challenge for scientists around the world.
Xiaodong team from Tianjin University's Department of Medicine put forward the concept of "cluster enzyme", which they successfully designed by means of single-atom regulation of a class of artificial enzymes with the precise structure of atoms - "cluster enzymes".
experiments show that "cluster enzyme" has high catalytic activity and selectivity, and its antioxidant activity is 160 times that of natural water-soluble vitamin E and 9 times that of anthocylin molecules.
results showed that the use of "cluster enzyme" agents can effectively reduce nerve inflammation in brain-damaged mice, significantly reducing the inflammatory factors in mice.
particularly noteworthy is that "cluster enzymes" are very small in size and can be naturally filtered out by the kidneys, which means that the use of "cluster enzymes" drugs can avoid damage to organs such as liver and kidneys.
" cluster enzyme" has broad application prospects in biomedical science, especially in neuroscience and engineering. Zhang Xiaodong, head of the
team, said, "Next, we will continue to improve the variability of the 'cluster enzyme', improve its targeting function, and tap into its potential for the treatment of Alzheimer's disease, brain damage and other major neural inflammation."