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Hemorrhoids are one of the most common anal diseases in clinical practice.
They can be divided into internal hemorrhoids, external hemorrhoids and mixed hemorrhoids according to the different locations.
Either way, hemorrhoids affect a large part of the world's population.
Therefore, there is a saying of "ten men with nine hemorrhoids, ten women with ten hemorrhoids".
This unspeakable discomfort can also affect the quality of life in severe cases.
However, until now, the pathogenesis and potential risk factors of hemorrhoids are still elusive.
In a study published on "Gut" on April 23, Beijing time, an international research team of nearly 100 people led by Monash University in Australia determined the cause of hemorrhoids by analyzing the genome data of nearly 950,000 people for the first time .
This study provides important insights for further understanding the pathogenesis of hemorrhoids.
Hemorrhoids are pathological hypertrophy of the anal pad at the lower end of the rectum, causing pain, itching, and sometimes bleeding, which restricts daily activities.
Most patients with hemorrhoids can use over-the-counter medications to solve this unspeakable concealment, but more severe patients require surgery.
It is generally believed that there are many risk factors for hemorrhoids, including sedentary sitting, obesity, too little dietary fiber intake, too long to go to the toilet or nervousness during defecation, and excessive force.
But few people will consider this issue from a genetic perspective.
In this study, the research team conducted a genome-wide association study (GWA) meta-analysis of 218,920 hemorrhoid patients and 725,213 healthy people from the British Biobank and a European population cohort study, and the relationship between hemorrhoids and other traits A variety of genetic correlation analyses were performed, and the polygenic risk scores of hemorrhoids were calculated, and their transformation potential in independent data sets was evaluated.
The analysis results show that hemorrhoids are genetically related to several other diseases in the digestive tract, neuroemotional and cardiovascular fields.
Researchers identified 102 independent hemorrhoid risk gene loci, these genes are expressed in blood vessels and gastrointestinal tissues, and jointly participate in the control of smooth muscle function and the development and integrity of intestinal epithelial and endothelial structures.
Therefore, the researchers concluded that hemorrhoids are caused by smooth muscle, epithelial and connective tissue dysfunction.
This study provides important new insights for the current lack of research on the pathogenesis of hemorrhoids, and points out some biological processes and pathways involved in the disease.
This lays the foundation for more detailed genetic and mechanism analysis, the development of alternative treatment methods for these pathways, and finally the effective preventive measures based on the calculated individual susceptibility.
Link to the paper: https://gut.
bmj.
com/content/early/2021/04/22/gutjnl-2020-323868 2020 Hot Article Selection 1.
The cup is ready! A full paper cup of hot coffee, full of plastic particles.
.
.
2.
Scientists from the United States, Britain and Australia “Natural Medicine” further prove that the new coronavirus is a natural evolution product, or has two origins.
.
.
3.
NEJM: Intermittent fasting is right The impact of health, aging and disease 4.
Heal insomnia within one year! The study found that: to improve sleep, you may only need a heavy blanket.
5.
New Harvard study: Only 12 minutes of vigorous exercise can bring huge metabolic benefits to health.
6.
The first human intervention experiment: in nature.
"Feeling and rolling" for 28 days is enough to improve immunity.
7.
Junk food is "real rubbish"! It takes away telomere length and makes people grow old faster! 8.
Cell puzzle: you can really die if you don't sleep! But the lethal changes do not occur in the brain, but in the intestines.
.
.
9.
The super large-scale study of "Nature Communications": The level of iron in the blood is the key to health and aging! 10.
Unbelievable! Scientists reversed the "permanent" brain damage in animals overnight, and restored the old brain to a young state.
.
.
They can be divided into internal hemorrhoids, external hemorrhoids and mixed hemorrhoids according to the different locations.
Either way, hemorrhoids affect a large part of the world's population.
Therefore, there is a saying of "ten men with nine hemorrhoids, ten women with ten hemorrhoids".
This unspeakable discomfort can also affect the quality of life in severe cases.
However, until now, the pathogenesis and potential risk factors of hemorrhoids are still elusive.
In a study published on "Gut" on April 23, Beijing time, an international research team of nearly 100 people led by Monash University in Australia determined the cause of hemorrhoids by analyzing the genome data of nearly 950,000 people for the first time .
This study provides important insights for further understanding the pathogenesis of hemorrhoids.
Hemorrhoids are pathological hypertrophy of the anal pad at the lower end of the rectum, causing pain, itching, and sometimes bleeding, which restricts daily activities.
Most patients with hemorrhoids can use over-the-counter medications to solve this unspeakable concealment, but more severe patients require surgery.
It is generally believed that there are many risk factors for hemorrhoids, including sedentary sitting, obesity, too little dietary fiber intake, too long to go to the toilet or nervousness during defecation, and excessive force.
But few people will consider this issue from a genetic perspective.
In this study, the research team conducted a genome-wide association study (GWA) meta-analysis of 218,920 hemorrhoid patients and 725,213 healthy people from the British Biobank and a European population cohort study, and the relationship between hemorrhoids and other traits A variety of genetic correlation analyses were performed, and the polygenic risk scores of hemorrhoids were calculated, and their transformation potential in independent data sets was evaluated.
The analysis results show that hemorrhoids are genetically related to several other diseases in the digestive tract, neuroemotional and cardiovascular fields.
Researchers identified 102 independent hemorrhoid risk gene loci, these genes are expressed in blood vessels and gastrointestinal tissues, and jointly participate in the control of smooth muscle function and the development and integrity of intestinal epithelial and endothelial structures.
Therefore, the researchers concluded that hemorrhoids are caused by smooth muscle, epithelial and connective tissue dysfunction.
This study provides important new insights for the current lack of research on the pathogenesis of hemorrhoids, and points out some biological processes and pathways involved in the disease.
This lays the foundation for more detailed genetic and mechanism analysis, the development of alternative treatment methods for these pathways, and finally the effective preventive measures based on the calculated individual susceptibility.
Link to the paper: https://gut.
bmj.
com/content/early/2021/04/22/gutjnl-2020-323868 2020 Hot Article Selection 1.
The cup is ready! A full paper cup of hot coffee, full of plastic particles.
.
.
2.
Scientists from the United States, Britain and Australia “Natural Medicine” further prove that the new coronavirus is a natural evolution product, or has two origins.
.
.
3.
NEJM: Intermittent fasting is right The impact of health, aging and disease 4.
Heal insomnia within one year! The study found that: to improve sleep, you may only need a heavy blanket.
5.
New Harvard study: Only 12 minutes of vigorous exercise can bring huge metabolic benefits to health.
6.
The first human intervention experiment: in nature.
"Feeling and rolling" for 28 days is enough to improve immunity.
7.
Junk food is "real rubbish"! It takes away telomere length and makes people grow old faster! 8.
Cell puzzle: you can really die if you don't sleep! But the lethal changes do not occur in the brain, but in the intestines.
.
.
9.
The super large-scale study of "Nature Communications": The level of iron in the blood is the key to health and aging! 10.
Unbelievable! Scientists reversed the "permanent" brain damage in animals overnight, and restored the old brain to a young state.
.
.
