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Innovation: In recent years, fatal viral infections have brought severe challenges to global public health.
Epigenetic regulation plays an important role in the complex relationship between virus and host.
You Fuping's group at Peking University School of Basic Medicine systematically summarized the relationship between virus-host chromatin open regulation from the perspective of epigenetics.
Keywords: antiviral innate immunity, epigenetics, chromatin remodeling, histone modification, the core of m6A epigenetics is the fine adjustment of chromatin structure through the covalent modification of histones or nucleotides.
And then regulate the expression of the gene when and where.
In the evolution of viruses and hosts and the "arms race", on the one hand, for the host, the orderly activation and enrichment of immune cells to the site of infection and subsequent effects depend on the rapid adjustment of chromatin structure; on the other hand, For viruses, limited to the size of their own genomes, they rely on epigenetic regulatory factors to achieve immune escape or antagonism.
In addition, the host's avoidance of excessive immune pathological reactions also depends on epigenetic regulation.
At the same time, the article also discussed the important role of RNA modification m6A in the virus-host relationship.
Finally, the author concluded that with the help of next-generation sequencing, including single-cell sequencing, we are expected to draw a virus-host epigenetic regulation map with higher resolution and considering different phases and higher-dimensional chromatin structures, and improve our understanding of Understanding of the relationship between virus and host.
The article was published online in European Journal of Immunology on May 8, 2021 in review format.
WILEY paper information: Epigenetic regulation in antiviral innate immunity.
Xiao Wang, Huawei Xia, Shengde Liu, Lili Cao, Fuping You.
European Journal of ImmunologyDOI: 10.
1002/eji.
202048975 Click "Read the original text" in the lower left corner to view the original text of the paper.
Introduction to the European Journal of Immunology "European Journal of Immunology" is an academic journal of the European Federal Society of Immunology, covering basic immunological research, focusing on antigen processing, cellular immune response, immune infection, immune regulation, clinical immunology, innate immunity, molecular immunity Learning, and other related new technologies.
Press and hold the QR code on the official WeChat platform of AdvancedScienceNewsWiley's scientific research information.
Follow us to share cutting-edge information｜Focus on scientific research trends to publish scientific research news or apply for information sharing, please contact: ASNChina@Wiley.
com
Epigenetic regulation plays an important role in the complex relationship between virus and host.
You Fuping's group at Peking University School of Basic Medicine systematically summarized the relationship between virus-host chromatin open regulation from the perspective of epigenetics.
Keywords: antiviral innate immunity, epigenetics, chromatin remodeling, histone modification, the core of m6A epigenetics is the fine adjustment of chromatin structure through the covalent modification of histones or nucleotides.
And then regulate the expression of the gene when and where.
In the evolution of viruses and hosts and the "arms race", on the one hand, for the host, the orderly activation and enrichment of immune cells to the site of infection and subsequent effects depend on the rapid adjustment of chromatin structure; on the other hand, For viruses, limited to the size of their own genomes, they rely on epigenetic regulatory factors to achieve immune escape or antagonism.
In addition, the host's avoidance of excessive immune pathological reactions also depends on epigenetic regulation.
At the same time, the article also discussed the important role of RNA modification m6A in the virus-host relationship.
Finally, the author concluded that with the help of next-generation sequencing, including single-cell sequencing, we are expected to draw a virus-host epigenetic regulation map with higher resolution and considering different phases and higher-dimensional chromatin structures, and improve our understanding of Understanding of the relationship between virus and host.
The article was published online in European Journal of Immunology on May 8, 2021 in review format.
WILEY paper information: Epigenetic regulation in antiviral innate immunity.
Xiao Wang, Huawei Xia, Shengde Liu, Lili Cao, Fuping You.
European Journal of ImmunologyDOI: 10.
1002/eji.
202048975 Click "Read the original text" in the lower left corner to view the original text of the paper.
Introduction to the European Journal of Immunology "European Journal of Immunology" is an academic journal of the European Federal Society of Immunology, covering basic immunological research, focusing on antigen processing, cellular immune response, immune infection, immune regulation, clinical immunology, innate immunity, molecular immunity Learning, and other related new technologies.
Press and hold the QR code on the official WeChat platform of AdvancedScienceNewsWiley's scientific research information.
Follow us to share cutting-edge information｜Focus on scientific research trends to publish scientific research news or apply for information sharing, please contact: ASNChina@Wiley.
com
