Zeng Songjun's research group of Hunan Normal University AS: Controlled biodegradation, endogenous H2S cycle-activated self-assembled nanoprobes for synergistic enhanced colon cancer-specific treatment

Abstract: Zeng Songjun's research group at the School of Physics and Electronic Science, Hunan Normal University has designed a novel endogenous H2S-triggered cobalt-doped POM-Co nanoprobe, which can achieve cyclic self-aggregation, controllable biodegradation and sustainable consumption of_H2S/GSH in response to H2S, which can be successfully used in synergistic enhanced tumor-specific photothermal and chemokinetic combination therapy
。

Keywords: _H2Scyclically activated nanomaterials, self-assembled nanoprobes, controlled biodegradation, precise/sustainable cancer treatment
.

Colon cancer is currently one of the three most common cancers in the
world.
Many treatments for colon cancer have been developed, but these traditional treatments are often accompanied by various side effects
.
Chemokinetic therapy (CDT) is a new, minimally invasive therapy that selectively induces apoptosis and necrosis
by converting overexpressed hydrogen peroxide (_H2O2) in tumors into active oxides.
However, the efficacy of CDT is still limited by the complex tumor microenvironment (highly expressed_H2Sand GSH)
of colon cancer.
Therefore, reshaping the tumor microenvironment of colon cancer by reducing_H2Sand GSH is extremely urgent and still faces great challenges
to improve the efficacy of CDT in colon cancer.
Photothermal therapy (PTT) is another new type of minimally invasive and controllable treatment in recent years, providing new opportunities
for the treatment of colon cancer.
However, most photothermal agents tend to exhibit sustained thermal effects and non-specific treatments, causing inevitable damage
to normal tissues surrounding the tumor.
In addition, inorganic nanoparticles remain in the body for a long time, posing a great threat
to health.
Therefore, the construction of biocontrollable degradable nanoprobes with endogenous_H2Sintelligent response is of great significance
for the realization of sustainable, precise and specific treatment of colon cancer.

Based on the above problems, Professor Zeng Songjun's research group of Hunan Normal University designed an endogenous_H2Sintelligent response Co-doped POM-Co nanocluster for the treatment of_H2S-richcolon cancer
.
After the designed nanocluster is activated by_H2S, it forms a large-size POM-CoS through self-assembly, which can not only effectively enhance the accumulation of tumor sites, but also activate its photothermal properties at the same time, so as to realize specific photothermal treatment
of tumors.
Moreover, the formed POM-CoS can be gradually biodegraded, releasing^CO2+ and^Mo6+ for Co(II)-catalyzed •OH generation and GSH-depleting ^Russellmechanism activated_1O2 production
, respectively.
More importantly, the designed nanoprobe has cyclic degradation and aggregation characteristics, which can continuously remove_H2S/GSH and produce reactive oxygen species to achieve precise and sustainable treatment
of colon cancer.
Therefore, this research provides a new strategy for designing biodegradable tumor microenvironment-driven smart nanoprobes, bringing new opportunities
for the realization of precise and sustainable anti-tumor therapy.

WILEY

Paper Information:

Recyclable endogenous H2S activation of self-assembled nanoprobe with controllable biodegradation for synergistically enhanced colon cancer-specific therapy

Junqing Huang, Zhiming Deng, Shenghui Bi, Xingwang Wen, Songjun Zeng*

Advanced Science

DOI: 10.
1002/advs.
202203902

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.

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