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SNX17 can increase LRP4 membrane expression, promote acetylcholine receptor aggregation, and improve EAMG
Time of Update: 2023-01-04
Keywords: myasthenia gravis; LRP4; Therapeutic targetsMyasthenia gravis ( MG) is most prominently characterized by impaired aggregation of the neuromuscular junction (NMJ), postsynaptic membrane (endp
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Biol Psychiatry︱ Tianming Gao's team reveals the regulation of astrocytes on adult hippocampal neurogenesis and memory through acetylcholine receptor M1
Time of Update: 2022-08-15
, Biol Psychiatry, 2022) Conclusion and discussion, inspiration and prospect Transgenic mice specifically knocked out muscarinic acetylcholine receptor M1 (Chrm1) on glial cells, combined with immunofluorescence staining, retroviral labeling, primary astrocyte culture, electrophysiology, western blotting, and behavior From the molecular, cellular and overall levels, it has been revealed that astrocytes sense cholinergic signals mediated by Chrm1, thereby regulating the neurogenesis of the adult hippocampus, and the mechanism may be through the release of BDNF ( Figure 8) .
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Interpretation of Science Frontier Review︱Regulatory mechanism of nicotinic acetylcholine receptor
Time of Update: 2021-10-01
In this review, the author systematically reviewed the close coordination of various accessory protein molecules involved in the process of subunit synthesis, folding assembly, cell membrane transport and functional activation of various nicotinic acetylcholine receptors (nAChRs) .
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The patient has drooping eyelids for 1 year and has positive acetylcholine receptor antibodies. What disease can you think of?
Time of Update: 2021-08-08
Physical examination: Drooping right eyelid, fixed right eyeball, bilateral pupils of equal size , Sensitive to light reflection, suspicious fatigue test, no abnormalities in the rest of the nervous system, no abnormalities in head MRI, no abnormalities in thymus CT, AchR(+) .
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JNNP: The change rate of acetylcholine receptor antibody levels predicts the prognosis of myasthenia gravis
Time of Update: 2021-04-17
In this study, the purpose of this article is to determine whether the newly developed rate of reduction of AChR-Ab levels (RR-AChRAb) measured before and after immunosuppressive therapy in this study reflects treatment response and predicts the prognosis of MG.
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Why does healthy brain need acetylcholine?
Time of Update: 2020-04-03
The brain is a complex organ composed of neurons, which are responsible for the generation of nerve impulse electronic activities To keep the brain working properly, many chemicals, including acetylch
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-activity relationship between α - conotoxin vc1.1 and human α 9 α 10 nicotinic acetylcholine receptor
Time of Update: 2019-09-08
Nicotinic acetylcholine receptor (nAChR) is the first transmembrane pentamer composed of five subunits It is a ligand gated ion channel protein that mediates the rapid signal transmission between syna
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Acetylcholine receptor (AChR) antibody-positive myasthenia gravis, from antibody to complement
Time of Update: 2022-10-21
The antigen-antibody complex in the patient activates complement, leading to a cascade that attacks the postsynaptic membrane at the neuro-muscular junction, leading to clinical signs of skeletal muscle weakness.
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Laurdan Studies of Membrane Lipid-Nicotinic Acetylcholine Receptor Protein Interactions
Time of Update: 2021-03-04
A hitherto unexploited property of Laurdan, namely its ability to act as a F�rster-type resonance energy transfer (FRET) acceptor of tryptophan emission, was used to learn about the physical state of lipids within F�rster distance from donor tryptophan residues in integral membrane proteins.
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Mouse Acetylcholine Transferase (ChAT) Enzyme-linked Immunoassay (ELISA)
Time of Update: 2021-02-25
With purified mice acetylcholine transferase (ChAT ) antibody pack is microplate, made of solid-phase antibodies, and added < "FONT-SIZE: 10.5pt; COLOR: rgb (0,0,0); > acetylcholine transferase (ChAT) and HRP mark acetylcholine transfer Enzyme (ChAT) antibody binds to form antibody -> < a href - enzyme-labeled antibody complex , after thorough washing < "FONT-SIZE: 10.5pt;"" > plus Base TMB color.
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Mouse Acetylcholine Transferase (ChAT) Enzyme-linked Immunoassay (ELISA)
Time of Update: 2020-11-22
mouse acetylcholine "> transfer enzyme (ChAT) ase-immune analysis ( ELISA ) reagents box instruction manual Reagents for research purposes only Purpose: This kit is used to determine mice serum plasma, cell serum and related liquid samples acetylcholine transferase (C < "FONT-WEIGHT: bold; FONT-SIZE: 12.0pt; COLOR: rgb (0,0,0); ">hAT ) < "FONT-SIZE: 12.0pt;" > content.
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Acetylcholine-energy neurons whole-brain map and pre-base brain choline neuron-mediated projection group
Time of Update: 2020-08-16
the study, based on a fully automatic microimaging method, the Brain-wide Positioning System (BPS), at a single-cell level, analyzed the location distribution of choline neurons in the whole brain and the fine morphological structure and projection maps of the neurons of the pre-brain choline energy.