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Scientists have cultivated mini brain organoids in the laboratory, which can mature like a baby's brain!
Time of Update: 2021-03-24
February 27, 2021 // - A few days ago, a research report titled "Long-term maturation of human cortical organoids matches key early postnatal transitions" was published in the international journal Nature Neuroscience , from the University of California and other institutions Scientists have cultivated a new type of mini brain organoid in the laboratory through research, which is as mature as a baby's brain.
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Zhao Yan's group reveals that the pathogenic genes WDR45 and WDR45B of nervous system diseases regulate the maturation of neuronal autophagosomes
Time of Update: 2021-03-24
This study revealed that WDR45/45B functions in the late stage of autophagy in nerve cells, mediating the fusion process of autophagosomes and lysosomes, and promoting the formation of autophagolysosomes.
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Science | Song Yuanbin/Shan Liang et al. Develop a new humanized mouse model of human red blood cell growth and maturation
Time of Update: 2021-03-23
In recent years, Stephanie Halene, as the corresponding author, has published many research papers in internationally renowned journals such as Science, Immunity, Blood, and Nature Communications.
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Daiichi Sankyo dismantles nearly 4.7 billion yen of mature drugs, accelerating the transformation into the field of oncology
Time of Update: 2021-03-19
Among them, 6 products will be transferred to Alfresa Pharmaceuticals in the form of a company split, which will take effect on December 1, 2021.
According to reports, even after the sale, Daiichi Sankyo will still be responsible for product manufacturing for the time being.
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Is Pfizer's mature drug "canary in a coal mine" in China?
Time of Update: 2021-02-25
in the second quarter, Pfizer's Upjohn, which has a pharmaceutical business, decided to merge with Mylan - plunging 20 percent in China, largely because quantity-based procurement systems are being tested in 11 major chinese cities.
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Acta Neuropathologica: The maturation of neuron AD-tau pathology includes cytostyte and synth tau
Time of Update: 2021-02-24
above, this study expands knowledge of the preclinical stages of AD, in particular the sequence of initial events that occur when tau aggregation is formed and the processes that occur when tau pathology spreads to unaffected brain regions.
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Use of Escherichia coli Mutator Cells to Mature Antibodies
Time of Update: 2021-02-20
Repeated rounds of mutation and increasingly stringent selection (Fig. 1 ) enable recovery of Abs of substantially elevated affinity for the target.
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Uncovering the mature mechanisms for the production of NK cells promises to lead to the development of new immunotherapy for cancer and infectious diseases
Time of Update: 2021-02-12
researcher Ewa Sitnicka explains that without the Notch signaling path, NK cells would not mature properly and their numbers would decline, which is important for NK cells to fight cancer and infectious diseases effectively; (Bio Valley)
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Quantitative Analysis of Phagocytosis and Phagosome Maturation
Time of Update: 2021-01-30
Phagocytosis of particles expressing or coupled to various fluorescent reporters and sensors can be used to monitor quantitatively various parameters of this central biological process.
We also describe methods to use fluorescent reporter dyes (FITC or DQgreen) coupled to silica beads to measure the kinetics of acidification and proteolysis.
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RNA Extraction from Developing or Mature Wheat Seeds
Time of Update: 2021-01-17
Purification of RNA from plant tissue especially from seed tissue can be challenging due to this high starch content.
Thus the removal of starch by using appropriate methods is necessary for obtaining pure RNA to be processed for functional genomics analysis.
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Genetic Transformation of Mature Citrus Plants
Time of Update: 2021-01-16
Invigoration of the source adult material, establishment of adequate transformation and regeneration conditions, and acceleration of plant development through grafting allowed us to produce transgenic mature sweet orange trees flowering and bearing fruits in a short time period.
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Pulsed-Field Gel Electmphoresis of Mature Bacteriophage P22 DNA
Time of Update: 2020-12-25
Microcomputers have now developed to the point that digital image processing can be a desktop procedure ( 4 ) that requires equipment (including computer, video camera, storage device, and laser printer) that costs less than $15,000.
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Hsp90 and Client Protein Maturation
Time of Update: 2020-12-19
The majority of identified Hsp90 clients are involved in signal transduction, including many steroid hormone receptors and kinases.
A handful of Hsp90 clients can be classified as nonsignal transduction proteins, including telomerase, cystic fibrosis transmembrane conductance regulator, and antigenic peptides destined for major histocompatibility complex.
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Development of a new protocol for 2-day generation of mature dendritic cells from human monocytes
Time of Update: 2020-11-26
We developed a new 2-day protocol for the generation of dendritic cells (DCs) from human monocytes in vitro .
After 48 hours of total culture period, expression of activation markers was more pronounced in cells generated by the 2-step differentiation and activation method.
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Soybean (Glycine max) Transformation Using Mature Cotyledonary Node Explants
Time of Update: 2020-11-21
Agrobacterium tumefaciens -mediated transformation of soybeans has been steadily improved since its development in 1988.
The cotyledonary-node method has been extensively investigated and across a number of laboratories yields on average greater than 1% transformation efficiency (one Southern-positive, independent event per 100 cotyledonary-node explants).