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Carl June, the father of CAR-T, commented: Beyond cancer, CAR-T successfully treats lupus erythematosus
Time of Update: 2023-01-04
On November 23, 2022, Professor Carl June, the "father of CAR-T" and the University of Pennsylvania, published a review article in the journal Cell entitled: CAR-T therapy extends its reach to autoimmune diseases [1], commenting on the very promising effect of CAR-T cell therapy in the treatment of patients with the autoimmune disease systemic lupus erythematosus.
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NEJM: CAR-T cell therapy successfully treats lupus erythematosus for the first time
Time of Update: 2021-08-27
The research team performed CAR-T cell therapy on a 20-year-old female patient with severe systemic lupus erythematosus.
This study shows that CAR-T cell therapy targeting CD19 can induce rapid remission of refractory systemic lupus erythematosus .
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Roche's new drug Gazyva treats lupus nephritis CRR up to 40%
Time of Update: 2021-02-24
November 11, Roche announced that its small-molecule drug for SMA, Risdiplam and CD20 monoantigen Gazyva, had achieved positive results in phase III SUNFISH studies and Phase II NOBILITY studies, respectively.
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Potential new ways to treat lupus
Time of Update: 2023-02-01
Dr. Jeffrey Rathmell (left) and Dr. Kelsey Voss led a multidisciplinary team that discovered that iron metabolism in T cells is a potential target for the treatment of lupusLupus, including systemic lupus erythematosus, occurs when the immune system attacks the body's own healthy tissues, causing pain, inflammation, and tissue damage.
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How is lupus nephritis treated? The ultra-practical experience of the experts got it
Time of Update: 2023-01-01
, Professor Zhang Hui gave the following suggestions for combination treatment regimen for different types of LN patients:● Compared with vocyclosporine, belimumab is more suitable for patients with LN with eGFR≤45 ml/min and/or significant chronicized renal biopsy and low proteinuria ().
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A new breakthrough in CAR-T cell therapy: successfully treating multiple patients with lupus erythematosus and achieving long-term drug-free remission
Time of Update: 2022-10-03
Written by Editor Wang DuoyuTypesettingWater into writingSystemic lupus erythematosus (SLE) is a severe autoimmune disease with an incidence of 0. 1% in the general population and mainly affects young
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Nat Med: A new breakthrough in CAR-T cell therapy: Successfully treating multiple patients
Time of Update: 2022-10-02
In the latest paper, the research team reported that five other patients with refractory systemic lupus erythematosus improved after treatment with CAR-T cells, with no recurrence at up to 17 months of follow-up and no drug remission.
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Hydroxychloroquine is used to treat patients with systemic lupus erythematosus and their dosage
Time of Update: 2022-09-30
SLEDAI scores of patients with SLE who are treated with conventional or low-dose HCQ at baseline, 3-month follow-up, and 6-month follow-up:Methods: Disease activity was assessed using SELENA-SLEDAI 2011 standard, cutaneous lupus erythematosus disease area and severity index (CLASI), and serum biomarkers.
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How to treat skin lupus erythematosus?
Time of Update: 2021-10-02
4) Tretinoin drugs are recommended as the second-line treatment of refractory CLE (especially hyperkeratotic skin lesions and verrucous lupus erythematosus), preferably combined with antimalarials .
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How to treat lupus renal microvascular disease?
Time of Update: 2021-06-04
A small part of SLE damages the kidney through non-immune complex pathways (such as lupus interstitial nephritis) or renal vascular disease.
Therefore, for SLE combined with TMA, it is necessary to comprehensively judge the patient's clinical manifestations and various laboratory indicators, and initiate treatment as soon as possible.
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How to reduce hormones to treat lupus?
Time of Update: 2021-03-25
. Figure 3 The specific compliance status of each standard/picture source Professor Yanjie Hao’s speech PPT The SLE-related diagnosis and treatment guidelines released in recent years emphasize that, when possible, the hormone dosage of SLE patients needs to be reduced to a minimum or even stopped.
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Is it possible to treat lupus with "zero hormone"?
Time of Update: 2021-03-23
Professor Zhao Juan believes that although lupus podocyte disease is relatively rare in lupus patients, it is a problem that cannot be ignored in the diagnosis and treatment of lupus nephritis.
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diseases, but may also be the "saviour" of treating autoimmune diseases such as lupus.
Time of Update: 2021-03-03
Ginger is often used as a Chinese medicine to treat chronic diseases such as asthma and arthritis due to its anti-inflammatory and antioxidant properties. There have been studies that have found that
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Lancet pheumatol: Under the skin to be treated with Anifrolumab systemic lupus erythematosus
Time of Update: 2020-12-13
Given that patients may find it more convenient to administer drugs under the skin than intravenously, the researchers evaluated the pharmacogenetics, efficacy, safety and efficacy of patients treating SLE, active dermatology, and high-type interferon genetic characteristics with under-skin injections.
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NEJM: Daremu monoantigen or is expected to treat a variety of autoimmune diseases such as systemic lupus erythematosus.
Time of Update: 2020-10-13
6, 2020 // -- In a recent study published in the international journal New England Journal of Medicine, scientists from the Charlett Medical University in Berlin and other institutions successfully tr