Blood: Lysine acetyl transferase 5 (Tip60) involved in the steady state maintenance of hematopoietic stem cells

HematopoieticStem Cells(HSC) replenishes the blood system throughout its life cycleTheir two defined characteristics, self-renewal and differentiation, are strictly controlled by epigenetic mechanismsknocked out mouse models through conditional genes, Numata et alfound that lysine acetyl transferase 5 (Kat5, also known as Tip60) was essential to maintain hSC steady state, both in fetal and adult mice;the genome-wide chromatin and transcriptional spectrum analysis of hematopoietic stem cells and progenitor cells in mice found that Tip60 and c-Myc were positioned in combination, and that knocking out Tip60 inhibited the expression of Myc target genes, which were closely related to important biological processes related to HSC steady state maintenance, cell cycle and DNA repairit is worth noting that acetylized H2A.Z (acHA.Z) is enriched on the active chromatin in combination with Tip60, and knocking out Tip60 induces acHA.Z/H2AThe Z-ratio dropped significantly, these findings reveal key epigenetic regulatory mechanisms (at least partial mechanisms) that activate The HSC of the Myc target gene through Tip60-dependent H2A.Z acetylation