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Peripheral arterial disease (PAD) is an atherosclerotic occlusive disease of the lower extremities that affects hundreds of millions of people worldwide
.
Its most severe presentation is chronic limb-threatening ischemia (CLTI), defined as the presence of ischemic rest pain, lower extremity ulceration, or gangrene lasting more than 2 weeks
Peripheral arterial disease (PAD) is an atherosclerotic occlusive disease of the lower extremities that affects hundreds of millions of people worldwide
Singapore has one of the highest rates of LEA due to diabetes (14.
In the population-based Singapore Chinese Health Study, researchers investigated diabetes and its interrelationships with hypertension
, body mass index (BMI) and smoking, and the risk of LEA due to CLTI .
Participants were interviewed at the time of recruitment (1993 to 1998), and 656 LEA event cases were identified in 2017 through linkage to a national hospital database
In the population-based Singapore Chinese Health Study, researchers investigated diabetes and its interrelationships with hypertension
The results showed that the HR (95% CI) for LEA risk was 13.
Kaplan-Meier survival curve of lower limb amputation for chronic limb-threatening ischemia (CLTI) in patients with a history of diabetes mellitus
Lower limb amputation for chronic limb-threatening ischemia (CLTI) in patients with a history of diabetes Kaplan-Meier survival curve for chronic limb-threatening ischemia (CLTI) in patients with a history of diabetes Kaplan-Meier survival curve of blood (CLTI)Overall, although diabetes increased the risk of developing LEA more than tenfold, increased hypertension and BMI did not further increase the risk of developing LEA in patients with diabetes, suggesting a common mechanistic pathway for these risk factors
.
In contrast, smoking may work through another pathway, so smoking increases LEA risk regardless of diabetes status
Overall, although diabetes increased the risk of developing LEA more than tenfold, increased hypertension and BMI did not further increase the risk of developing LEA in patients with diabetes, suggesting a common mechanistic pathway for these risk factors
Reference: Ying, AF, Tang, TY, Jin, A.
et al.
Diabetes and other vascular risk factors in association with the risk of lower extremity amputation in chronic limb-threatening ischemia: a prospective cohort study.
Cardiovasc Diabetol 21, 7 (2022).
https://doi.
org/10.
1186/s12933-021-01441-0 Reference: Ying, AF, Tang, TY, Jin, A.
et al.
Diabetes and other vascular risk factors in association with the risk of lower extremity amputation in chronic limb-threatening ischemia: a prospective cohort study.
Cardiovasc Diabetol 21, 7 (2022).
https://doi.
org/10.
1186/s12933-021-01441-0Reference: Ying, AF, Tang, TY, Jin, A.
et al.
Diabetes and other vascular risk factors in association with the risk of lower extremity amputation in chronic limb-threatening ischemia: a prospective cohort study.
Cardiovasc Diabetol 21, 7 (2022).
https://doi.
org/10.
1186/s12933-021-01441-0 https://doi.
org/10.
1186/s12933-021-01441-0 Leave a comment here
