Diabetes: Changes in sleep disturbance, energy intake, and body synthesis during weight loss in a weight loss trial.

OBJECTIVE: To investigate the relationship between sleep disturbance and changes in body weight and body composition, and the mediating role of changes in appetite and food cravings in the 2-year Weight Loss Diet Intervention Trial, which included 810 overweight or obese individuals assessed for baseline sleep disturbance Individuals, who were randomly assigned to one of four diets, varied in their macronutrient content
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Changes in body weight and fat distribution were assessed by dual x-ray absorptiometry (DXA) and computed tomography (CT) during the 2-year intervention period .

Changes in body weight and fat distribution were assessed by dual x-ray absorptiometry (DXA) and computed tomography (CT) during the 2-year intervention period

Table 1 Patterns of omission in 810 participants over 2 years from baseline assessment of sleep disorders

Table 1 Patterns of omission in 810 participants over 2 years from baseline assessment of sleep disorders

Table 2 Overall change (Δ) from baseline to 6 months and from 6 months to 24 months in measures of obesity and energy expenditure according to sleep disturbance

Table 2 Overall change (Δ) from baseline to 6 months and from 6 months to 24 months in measures of obesity and energy expenditure according to sleep disturbance

Table 3 Weight loss outcomes after considering each moderator separately for 0-6 months using the new sleep disorder category (n=648) (n=648)

Table 3 Weight loss outcomes after considering each moderator separately for 0-6 months using the new sleep disorder category (n=648) (n=648)

Conclusions: During weight loss, more severe sleep disturbance was associated with an increased risk of weight loss failure during dietary intervention
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Food cravings and eating behaviors may moderate these links to some extent

During weight loss, more severe sleep disturbances were associated with an increased risk of weight loss failure during dietary interventions

Sleep Disturbance, Changes in Energy Intake and Body Compositing During Weight Loss in the POUNDS LOST Trial.
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