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Nature of Central South University published an article: A novel metabolic mechanism of iron death in tumor cells
Time of Update: 2023-02-03
Professor Yang Minghua's team of Pediatrics from the Third Xiangya Hospital of Central South University published original research results entitled "The lipid flippase SLC47A1 blocks metabolic vulnerability to ferroptosis" in the international authoritative academic journal Nature Communications, revealing the novel metabolic mechanism of iron death in tumor cells.
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Nature: The central function of innate immune cells was discovered
Time of Update: 2022-11-14
" In future research projects, Dr. Klose and his team hope to investigate whether innate lymphoid cells regulate other aspects of the immune response.
" In future research projects, Dr. Klose and his team hope to investigate whether innate lymphoid cells regulate other aspects of the immune response.
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Human induced pluripotent stem cells differentiate into hypothalamic vasopressin neurons
Time of Update: 2022-11-04
Differentiation of human induced pluripotent stem cells into hypothalamic vasopressin neurons with minimal exogenous signals and partial conversion to the naive state.
Differentiation of human induced pluripotent stem cells into hypothalamic vasopressin neurons with minimal exogenous signals and partial conversion to the naive state.
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Cell Journal (IF=17) Zu Xiongbing's team at Central South University discovered a safe
Time of Update: 2022-11-01
Immune checkpoint blockade (ICB), including anti-PD-1/PD-L1, has shown promising survival benefits and revolutionized the status quo of treatment for patients with advanced MIBC.
Original link: #—END—content is 【iNature】 Immune checkpoint blockade (ICB), including anti-PD-1/PD-L1, has shown promising survival benefits and revolutionized the status quo of treatment for patients with advanced MIBC.
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Cell sub-journal: Zu Xiongbing's team at Central South University discovered a safe and effective
Time of Update: 2022-10-25
OnOctober192022, the Zu Xiongbing team of Central South Universitypublished an online titleCell Reports Medicine(IF=17 Research paper "Neoadjuvant immunotherapy, chemotherapy, and combination therapy in muscle-invasive bladder cancer: A multi-center real-world retrospective study", To parallelize neoadjuvant immunotherapytislelizumab(gemcitabine and cisplatin),and neoadjuvant combination therapy(tislelizumab+ GC)exploring predictors of efficacy, which conducted a multicenter, real-world cohort study that demonstrated the highest rates of complete response and pathologic de-staging compared with neoadjuvant immunotherapy or chemotherapy.
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"Transitory peptide" in vivo delivery of Cre recombinase into mouse central nervous cell transduction efficiency ≥ AAV transduction!
Time of Update: 2022-10-14
summarySimple co-injection of Cre recombinase with HIV-TAT peptide successfully delivered Cre to mouse nerve cells, and Cre's delivery successfully activated the expression of reporter genes in neurons and astrocytes in the cerebral cortex without causing tissue damage, and its transduction efficiency was comparable or better than that of commonly used adeno-associated viruses.
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Front Cell Neurosci Review—Gamma Neural Oscillations and Central Nervous System Disorders: Mechanisms and Therapeutic Advances
Time of Update: 2022-09-15
Written by Guan Ao, Wang Shaoshuang, Huang Ailing, Deng Bin, Wang QiangEditor-in-charge - Wang SizhenEditor — Binwei YangNeural oscillations are rhythmic fluctuations over time in the firing activity
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Central memory T cells are the most potent precursors of resident memory T cells in human skin
Time of Update: 2022-08-11
. effector memory T cells (TRelative length unit) has the highest conversion rateRinggitin vitro and in vivo, but central memory T cells (Tcentimeter) lasts longer in the cycle, enters the skin in greater quantities, and produces more TRinggitAll in all, Tcentimeteris a highly efficient precursor to human skinRinggit, a feature that may underlie their known association with effective long-term immunity .
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"Cell Metabolism": Ptprd was first discovered to be a specific receptor of the appetite-stimulating hormone Asprosin in the central nervous system
Time of Update: 2022-04-26
But Atul Chopra's team found that Olfr734 was not expressed in AgRP neurons that respond to Asprosin and mediate the appetite-regulating effect of Asprosin .
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A multi-institution retrospective analysis of central nervous system recurrence of ASHT cell lymphoma in 2021
Time of Update: 2021-12-30
Research background Studies have identified risk factors for recurrence of the central nervous system (CNS) in patients with lymphoma, such as high tumor burden and extranodal (EN) disease .
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New discovery: fat cells play a central role in cognitive decline and neurodegenerative diseases
Time of Update: 2021-11-16
However, the overexpression of adipocyte-specific NaKtide induced by doxycycline significantly slowed the increase of inflammatory factors, body weight and blood sugar in mice fed Western diet .
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iScience: Fat cells play a central role in cognitive decline and neurodegenerative diseases
Time of Update: 2021-11-13
Role of Adipocyte Na, K-ATPase Oxidant Amplification Loop in Cognitive Decline and NeurodegenerationThe study showed that fat cells control the systemic response to brain function, leading to impaired memory and cognitive abilities in mice .
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Central South University Cell Metabolism publishes a paper: Senescent cells release granular calcineurin to promote bone aging
Time of Update: 2021-11-01
With funding from the National Natural Science Foundation of China (approval numbers: 81930022, 91749105, 81922017), the Luo Xianghang team at Xiangya Hospital of Central South University has made progress in the research of osteoporosis prevention and treatment .
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The Oncologist: The efficacy of immunotherapy in the treatment of metastatic non-small cell lung
Time of Update: 2021-08-13
Recently, research teams from Central and Eastern European countries have carried out real-world studies to evaluate the efficacy of immunotherapy for re-metastatic non-small cell lung cancer (NSCLC) .
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Nat Med: Clinical study of local infusion of HER2-specific CAR-T cells in the treatment of children
Time of Update: 2021-08-03
The interim report also supports the feasibility of generating HER2-specific CAR-T cells by repeated dosing regimens, indicating that their delivery in the central nervous system may be well tolerated and can activate local immunity in children and young patients.