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JCI: Improve the metabolism of macrophages and repair damaged nerves
Time of Update: 2021-10-22
The study, by selectively knocking out and overexpressing MCT1 in macrophages, found that MCT1 contributes to the metabolism, phenotype and function of macrophages and supports peripheral nerve regeneration, proving that regulating macrophage metabolism can promote peripheral nerve damage Recovery .
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The "double-edged sword" of Dev Cell neurons—Xiao Bo's team reveals a new mechanism by which lactic acid induces peripheral nerve damage
Time of Update: 2021-10-22
On October 6, 2021, a research team led by Professor Xiao Bo from the School of Life Sciences of Southern University of Science and Technology published an article Rheb-regulated mitochondrial pyruvate metabolism of Schwann cells linked to axon stability in the Journal of Developmental Cell, and found that peripheral glial cells-Schwann The pyruvate-lactic acid conversion metabolism regulated by Rheb in cells is very important for maintaining the stability of axons in the peripheral nervous system .
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New advances in DON-induced muscle cell damage and accurate detection of major derivatives
Time of Update: 2021-10-21
On October 1, 2021, the international academic journal Ecotoxicology and Environmental Safety published an online publication titled "Mycotoxin deoxynivalenol affects myoblast differentiation via downregulating cytoskeleton and ECM-integrin-FAK-RAC-PAK signaling" by the Wu Aibo research group of the Shanghai Institute of Nutrition and Health, Chinese Academy of Sciences.
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Stem cell transplantation: how skin-derived T cells damage other organs
Time of Update: 2021-10-20
In skin samples from patients before and after transplantation, Stary and research author Johanna Strob were able to prove that host-derived T cells in the skin tissue are responsible for the inflammation .
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Staying in space for a long time can cause brain damage
Time of Update: 2021-10-20
Image: Henrik Zetterberg, Nicholas Ashton and Kaj BlennowSource: University of GothenburgStaying in space for a long time seems to cause brain damage .
Evidence of brain damageThey collected blood samples from the astronauts 20 days before heading to the International Space Station .
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How deeply processed foods damage the memory of the aging brain
Time of Update: 2021-10-20
The results of the study also showed that supplementing DHA in processed foods consumed by elderly rats effectively prevented the increase in brain inflammation and behavioral signs of memory loss .
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Do not do things that damage joints on World Health Day!
Time of Update: 2021-10-20
When climbing stairs or mountains, in addition to increasing the weight bearing of the knees, the knees must also move back and forth and twist sideways, which will cause wear and tear on the soft tissues of the meniscus and other joints.
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Researchers have discovered a protein that can prevent severe brain damage and reduce the risk of fatal HSV-1 infection
Time of Update: 2021-10-19
A new study by researchers at the University of Illinois at Chicago shows that a mechanism can prevent the herpes simplex virus from causing severe brain damage and death .
During herpes infection, mTORC2 activates the cell survival mechanism of the eye and neuronal tissues .
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J HEPATOLOGY: Anti-TNF-α drug-liver damage caused by infliximab
Time of Update: 2021-10-10
The median time from the onset of liver injury to the peak ALT of patients receiving corticosteroid therapy was longer, 22 (12-59) days and 0 (0-3) days (p=0.
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OMCL: Yishen Paidu Decoction protects diabetic kidney damage by inhibiting oxidative stress, inflammation and epithelial-mesenchymal transition in mice
Time of Update: 2021-10-09
Various biochemical indicators (fasting blood glucose, blood creatinine, blood urea nitrogen, 24h urine total protein, total cholesterol, total triglycerides), improve renal pathological changes and renal tissue fibrosis, significantly inhibit oxidative stress and inflammatory cytokines (TNF-α, IL-6, IL-1β and monocyte chemoattractant protein-1) levels significantly reduce renal fibrosis, and inhibit transforming growth factor-β-1/Smad pathway to inhibit epithelial to mesenchymal transition.
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exposure damages the zebrafish brain and affects neurotransmitters and behavior
Time of Update: 2021-10-01
1c03457 Picture summary Introduction to the results recently The team of Professor Xie Lingtian (Chemical Pollution and Risk Control Team) of the Environmental Research Institute of South China Normal University, Li Xiao, a PhD student, and Liu Hongsong, a master student, published a titled "Dietary Seleno-L" in the top journal Environmental Science & Technology in the international environmental field.
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Alzheimer's disease new amyloid in the liver can damage the brain through the blood
Time of Update: 2021-10-01
Recently, a new study published in the open journal "PLOS Biology" found that beta amyloid produced in the liver is carried to the brain through lipoproteins in the blood, leading to neurodegeneration of the brain .
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Can't use levofloxacin or moxifloxacin for liver damage?
Time of Update: 2021-09-30
1 Guiding Principles for the Clinical Application of Antimicrobial Drugs The "Guiding Principles for the Clinical Application of Antimicrobial Drugs (2014 Edition)" even directly wrote: patients with impaired liver function, quinolone antibiotics such as levofloxacin, do not need to be reduced .
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Cardiovascular and cerebrovascular diseases: vascular endothelial damage is the initial factor, and dyslipidemia is an important factor
Time of Update: 2021-09-30
Academician Zhang Yun said that evidence-based research has produced a series of exciting results, confirming that Tongxinluo can safely and effectively reduce carotid intima-media thickness, plaque area and blood vessels in patients with subclinical arteriosclerosis.
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Clin Gastroenterology H: Severe liver damage during hospitalization of COVID-19 patients has nothing to do with liver insufficiency or death
Time of Update: 2021-09-29
The purpose of this study is to determine whether the significant increase in AST levels during hospitalization of COVID-19 patients is directly related to the common cause of liver damage in COVID-19 and whether it is independently related to liver insufficiency and/or death .