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Nature Immunology: Cytokines secreted by T cells
Time of Update: 2023-02-03
Human Th17 cells engage gasdermin E pores to release IL-1α upon NLRP3 inflammasome activation "We don't know how IL-1α is made in T cells and how it is released from the cell," said first author Chao Ying-Yin. The research was part of her doctoral dissertation, and she now works at an international biotech company in Munich, Germany, developing T-cell therapies.
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Stem Cell Rep: Scientists use stem cells to create a large number of human astrocytes that secrete
Time of Update: 2023-02-03
In the brain, the complement system plays a vital role in the normal development of the body and the immune response and synaptic elimination during the onset of disease; Inflammation in the brain an
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Scientists have found that secreted proteins help with muscle repair and growth
Time of Update: 2023-02-01
Source: Tokyo Metropolitan UniversityScientists at Tokyo Metropolitan University have discovered that a protein called platelet-derived growth factor B sub-(PDGF-B) is continuously secreted from skeletal muscle cells and helps repair muscle by encouraging myoblasts (muscle stem cells) to proliferate.
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IDH1 mutant glioma stem cells secrete G-CSF to improve the effect of immunotherapy
Time of Update: 2023-02-01
The results of this study showed that immunotherapy (TK/Flt3L) was effective in mIDH1 glioma due to the reprogramming of myeloid cells infiltrated in the tumor microenvironment.
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Fighting insomnia is just one step! Studies have shown that the thicker the quilt, the more melatonin is secreted...
Time of Update: 2023-01-06
Research process 02 02For the study, researchers selected 26 young, healthy participants, including 15 men and 11 women, to investigate whether the use of a thick quilt (about 12% of body weight) before bed resulted in higher concentrations of melatonin and oxytocin in saliva than light quilt (about 2.
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Fighting insomnia is just one step! Studies have shown that the thicker the quilt, the more melatonin is secreted...
Time of Update: 2023-01-06
Research process 02 02For the study, researchers selected 26 young, healthy participants, including 15 men and 11 women, to investigate whether the use of a thick quilt (about 12% of body weight) before bed resulted in higher concentrations of melatonin and oxytocin in saliva than light quilt (about 2.
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A&R: Extramucosal formation and prognostic value of secreted antibodies in rheumatoid arthritis
Time of Update: 2022-08-11
Objectives: Recent advances suggest that mucosal surfaces are important early in the development of rheumatoid arthritis (RA), especially in anti-citrullinated protein antibody (ACPA)-positive disease .
Rheumatoid Arthritis Studies in RA include levels of secreted Ig including ACPA and possible extramucosal formation .
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New direction for research and development of hypoglycemic drugs: a protein secreted by the liver can lower blood sugar
Time of Update: 2022-07-04
Recently, Xinhua News Agency reported that researchers from Australia and other countries found that when the blood sugar level in the experimental mice is too high, the liver secretes a protein called secretory modular calcium binding protein 1, and animal experiments have shown that it is harmful to diabetes.
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Nature Cancer: Reprogrammed macrophages stimulate vascular cells to secrete proteins and promote cancer metastasis
Time of Update: 2022-05-13
The team's experiments in mice transplanted with human breast cancer cells showed that the reprogrammed macrophages stimulated vascular cells to secrete a mix of metastasis-promoting proteins that are part of the metastatic niche .
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Nature sub-journal: Food cravings during pregnancy are derived from dopamine secreted by the brain
Time of Update: 2022-04-27
The authors reveal that pregnancy affects brain connectivity, particularly components of the dopamine circuit that is involved in the perception of rewarding stimuli and drives food-craving-like behaviors .
Nature Metabolism also distributed a review article entitled: Dopamine drives food craving during pregnancy .
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Nature sub-journal: Food craving during pregnancy stems from dopamine secreted by the brain
Time of Update: 2022-04-16
This study in mice shows that food cravings during pregnancy are driven by dopamine signaling in the brain's reward system .
The authors reveal that pregnancy affects brain connectivity, particularly components of the dopamine circuit, which is involved in the perception of reward stimuli and drives food-craving-like behaviors .
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Arthritis Rheumatol: Extramucosal formation in rheumatoid arthritis and prognostic value of secreted antibodies
Time of Update: 2022-01-21
Patients with early-stage rheumatoid arthritis who were at high risk for developing arthritis during follow-up (39/82) had higher baseline TSIGA levels compared to those who did not develop arthritisConclusion: Circulating secretory immunoglobulins were elevated before and during the onset of RA .
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Nature: Immune cells actually secrete neurotransmitters to limit tumor immunity
Time of Update: 2021-11-13
Lack of B cells or specific inactivation of GABA-producing enzyme GAD67 in B cells can enhance anti-tumor responseTherefore, the results of the study show that in addition to cytokines and membrane proteins, small metabolites derived from B cells also have immunomodulatory functions, which may be a pharmaceutical target that allows fine-tuning of the immune response .
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Nat Commun: Intestinal bacteria of colorectal cancer patients secrete butyrate to promote tumor formation
Time of Update: 2021-10-10
The invasion of these bacteria has been observed in CRC tissues, which is consistent with the increase in butyrate levels and the signs of aging-related inflammation .
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Cell: Cancer’s accomplice, new research has found that secreted gel protein can inhibit the body’s cancer immunity
Time of Update: 2021-06-28
sGSN inhibits the activity of DNGR-1 and at the same time inhibits the DNGR-1-dependent cross-presentation of dead cell-related antigens in tumors by cDC1, thereby promoting cancer immune evasion .