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Transl Lung Cancer Res: Influence of previous thoracic radiotherapy (RT) on the efficacy
Time of Update: 2022-03-04
Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase 2 Trial ALTER 1202 Shows that anlotinib Extends Progression-Free Survival (PFS) and Overall Survival (OS) in Patients with Relapsed Small Cell Lung Cancer (SCLC) .
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Transl Lung Cancer Res: The efficacy of pembrolizumab (pembrolizumab) alone or in combination
Time of Update: 2022-03-04
30-40% of Shanghai Chest Hospital affiliated to Shanghai Jiaotong University and multi-center conducted a retrospective study to evaluate the efficacy of pembrolizumab (pembrolizumab) alone or in combination in the treatment of patients with advanced non-small cell lung cancer with bone metastases .
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Sci Transl Med Hua Fang / Zhang Haizeng discovers a potential therapeutic target for colorectal
Time of Update: 2022-01-26
Editor's note iNature is China's largest academic public account. It is jointly created by doctoral teams from Tsinghua University, Harvard University, Chinese Academy of Sciences and other units.
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Sci Transl Med published 2 back to back!
Time of Update: 2022-01-06
On December 15, 2021, Professor Li Hongliang’s team published two articles titled "Multiple omics study identifies an interspecies conserved driver for nonalcoholic steatohepatitis" and "A small molecule targeting ALOX12" in the top international journal Science Translational Medicine.
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Sci Transl Med︱New Discovery!
Time of Update: 2021-11-14
Through human genetic and pathological analysis and functional analysis in cell and animal models, the research team proved that the APOE3-Jacksonville (V236E) variant can promote the aging of healthy brains, reduce Aβ by reducing APOE self-association and increasing lipidation And found that this gene mutation can improve Aβ-related APOE production, plaque load and toxicity .
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Sci Transl Med︱ Xiang Xianyuan and others revealed the crazy sugar phagocytosis of brain immune
Time of Update: 2021-11-05
Xiang Xianyuan (first author of the article), Matthias Brendel, Christian Haass (co-corresponding author) of the University of Munich and others published an online publication on Science Translational Medicine entitled "Microglial activation states drive glucose uptake and The article titled "FDG-PET alterations in neurodegenerative diseases" revises people's understanding of brain FDG-PET imaging and helps early diagnosis of neurodegenerative diseases .
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Sci Transl Med Sichuan University Cao Zhongwei/Chen Liping/Ding Yisen found that vascular
Time of Update: 2021-10-22
This research uses Multi-omics analysis of human cirrhosis, western diet and carbon tetrachloride (CCl4)-induced mini-pig NASH model and transgenic mice to reveal the landscape of the vascular adaptation group at the single-cell level, including endothelial cells (ECs) and TH17 Together, the cells cause liver cirrhosis .
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TRANSL PSYCHIAT: Does this medicine have a laxative effect and is "rejuvenating"?
Time of Update: 2021-10-20
In the post-scan recall task, the procapride group was more accurate than the placebo group in distinguishing the target image (novelty + familiarity) from the distractor (F(1,38) = 5.
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Transl Oncol: Metformin-salicylic acid treatment can improve prostate cancer treatment
Time of Update: 2021-09-29
Diabetic metforminRecently, researchers from Canada published an article in "Transl Oncol", investigating whether MET+SAL treatment can enhance PrCa tumor suppression and improve the response to RT .
Combined metformin-salicylate treatment provides improved anti-tumor activity and enhanced radiotherapy response in prostate cancer; drug synergy at clinically relevant doses .
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Transl Psychiatry: Pay attention to mental health during the epidemic lockdown and prescribe the right medicine
Time of Update: 2021-08-03
This effect is different from post-traumatic growth because it does not require internal psychological processes, but changes in the social environment caused by the adversity experienced together, such as the current COVID-19 pandemic .
1038/s41398-021-01508-2Ahrens, KF, Neumann, the RJ, Kollmann, B.
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Sci Transl Med: mRNA nanomedicine combined with PD-1, significantly improve cancer treatment effect
Time of Update: 2021-07-31
Therefore, the research team further investigated whether PTEN's restoration of anti-tumor immunity can improve the therapeutic effect of immune checkpoint inhibitors in PTEN mutant melanoma models .
The experimental results show that in the PTEN mutant melanoma model, mPTEN@NPs combined with anti-PD-1 monoclonal antibody can significantly improve the tumor treatment effect .
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Transl Psychiatry: Student mental health problems cannot be solved spontaneously through virus control
Time of Update: 2021-06-10
Since school resumption schedules vary from city to city, compared with continuing to study at home, there is a rare opportunity to observe the psychological and behavioral problems of children and adolescents in the early resumption of classes after the new coronary pneumonia pandemic .
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Sci Transl Med︱ A new mechanism to improve the pathology of Alzheimer's disease
Time of Update: 2021-06-05
The researchers used PACAP to target PAC1R to eliminate tau protein in the postsynaptic compartment of the mouse brain by increasing PKA signaling and enhancing proteasome activity (Figure 4).
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Am J Transl Res: The effect of propofol combined with estamine anesthesia induction
Time of Update: 2021-06-04
The control group was induced with propofol combined with sufentanil, and the experimental group was anesthetized with propofol combined with esketamine Induction; compare the hemodynamics, stress and inflammatory response, cognitive function changes, perioperative related indicators and adverse reactions between the two groups of patients.
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Sci Transl Med: Can the metastatic sentinel lymph node be detected by taking a photo during cancer surgery?
Time of Update: 2021-05-20
In the operating room, during the surgical resection of 18 breast cancer patients, the image sensor used clinically approved near-infrared fluorophores to further locate the sentinel lymph nodeIn summary, the flexibility and performance provided by this simple and compact architecture highlights the advantages of bio-inspired sensors in image-guided surgery .