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Tranquilizer metabolism and toxicology
Time of Update: 2021-10-01
In serum, benzodiazepines are tightly bound to serum albumin, and are eliminated in urine mainly in the form of hydroxyl compounds and glucuronic acid conjugates and corresponding compounds produced in the liver.
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Metabolism and Toxicology of Nitroimidazole Drugs
Time of Update: 2021-09-30
MNZ is mainly excreted through urine, 6% to 18% are excreted in the original form of drugs, MNZOH accounts for 24% to 28%, 2-methyl-5-nitroimidazole-1-acetic acid accounts for 12% to 20%, 1 -(β-Hydroxyethyl)-2-carboxy-5-nitroimidazole accounts for 8% to 12%, 14% of the dose is excreted through feces, and activated by intestinal microorganisms as active intermediates when excreted through feces .
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Metabolism and toxicology of pyrazolones
Time of Update: 2021-09-30
Figure 14-2 Metabolic route of Analgin and AminopyrineThe half-life of antipyrine in the human body is 13-15h, the volume of distribution is 0.
The binding rate of phenylbutazone and plasma protein is relatively high, from 93% to 98% in dairy cows and more than 98% in horses.
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Quinoxaline Drug Metabolism and Toxicology
Time of Update: 2021-09-30
Metabolism studies of liver microsomes in vitro incubation system show that the main metabolic pathway of OLQ is N→O group reduction, followed by side chain hydroxyl oxidation, N4-dehydroxyethylation and hydroxylation, and there are species differences.
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Xiao Xilong, one of the founders of animal toxicology in my country, dies
Time of Update: 2021-09-28
Xiao Xilong, one of the founders of animal toxicology in my country, passed away at the age of 63 Xiao Xilong, one of the founders of my country's animal toxicology, passed away at
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Metabolism and Toxicology of Macrolides and Lincosamide Drugs
Time of Update: 2021-09-20
The old varieties mainly cause gastrointestinal reactions, nervous system toxicity, cardiotoxicity, and occasionally cause kidney damage, ototoxicity, allergic purpura, hypertrophic pyloric damage, liver damage, allergic reactions and other adverse reactions .
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Beta-lactam drug metabolism and toxicology
Time of Update: 2021-09-20
2. 1 Metabolic processes in the body(1) PenicillinsPENs that can be absorbed orally include penicillin V, ampicillin , amoxicillin , oxacillin , cloxacillin , dicloxacillin, and flucloxacillin .
Allergic reactions to PENs are more common, ranking first among various drugs .
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The metabolic process and toxicology of nitrofuran metabolites in the body
Time of Update: 2021-09-20
The metabolic mechanism of NFs in animals is relatively complicated, and eventually they can form stable metabolites that are tightly combined with proteins.
Through the metabolism study of 13 C isotope-labeled furazolidone, it is found that its metabolites can be tightly combined with proteins to form a stable residue .
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Steroid Anabolic Hormone Drug Metabolism and Toxicology
Time of Update: 2021-09-20
After undergoing phase I and phase II metabolic reactions in the body, ASs and their metabolites are all polyhydroxy substances, and the proportion of conjugates in animal urine, bile or liver and kidney tissues is usually high .
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Metabolism and Toxicology of Non-steroidal Anabolic Hormone Drugs
Time of Update: 2021-09-20
ZON has two main metabolic pathways combined with glucuronic acid , reduced to ZOL, does not accumulate in the body, and has different metabolites in different animals: it is mainly degraded to β-ZOL in cattle, a-ZOL in pigs, and a-ZOL in mice.
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Glucocorticoids metabolism and toxicology
Time of Update: 2021-09-20
Long-term use of GCs at super-physiological doses can cause fat metabolism disorders, manifested as central obesity, and induce fatty liver .
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Metabolism and Toxicology of Tetracyclines
Time of Update: 2021-09-19
When repeated administration, the general clinical dose, the drug discharged in the original form in the urine can reach the required concentration in the urine to inhibit the growth of sensitive bacteria .
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Quinolones metabolism and toxicology
Time of Update: 2021-09-19
1 Metabolic processes in the bodyIn addition to the low absorption rate of NOR (about 15% of the dose of FQs), most drugs are quickly and completely absorbed after oral administration, usually up to 60% or higher, and the peak plasma concentration is 1 to 2 hours after administration.
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Metabolism and Toxicology of β-Agonist Drugs
Time of Update: 2021-09-04
There is no such result in the brand and other organs, which may be related to the accumulation of toxicity caused by clenbuterol hydrochloride residues in the liver and kidney .
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Metabolism and Toxicology of Aminoglycosides
Time of Update: 2021-09-04
(2) Kidney toxicityAGs are mainly excreted by the kidneys in their original form, and they can also accumulate large amounts of drugs in the renal cortex through cell membrane phagocytosis, which can cause nephrotoxicity, ranging from swelling of the renal tubules to severe renal tubular necrosis, but generally does not damage the glomeruli .
